Journal of Science and Medicine in Sport
Volume 13, Issue 4 , Pages 424-428 , July 2010

Serum collagen-derived peptides are unaffected by physical training in older sedentary subjects

Received 8 January 2009 ,Revised 18 May 2009 ,Accepted 10 August 2009.

References 

  1. Pugh KG, Wei JY. Clinical implications of physiological changes in the aging heart. Drugs Aging. 2001;18:263–276
  2. Jugdutt BI. Remodeling of the myocardium and potential targets in the collagen degradation and synthesis pathways. Curr Drug Targets Cardiovasc Haematol Disord. 2003;3:1–30
  3. Song Y, Yao O, Zhu J, Luo B, Liang S. Age-related variation in the interstitial tissues of the cardiac conduction system; an autopsy study of 230 Han Chinese. Forensic Sci Int. 1999;104:133–142
  4. Klima M, Burns TR, Chopra A. Myocardial fibrosis in the elderly. Arch Pathol Lab Med. 1990;114:938–942
  5. Burkauskiene A, Mackiewicz Z, Virtanen I, Konttinen YT. Age-related changes in myocardial nerve and collagen networks of the auricle of the right atrium. Acta Cardiol. 2006;61:513–518
  6. Jin D, Takai S, Sugiyama T, Hayashi T, Fukumoto M, Oku H, et al. Long-term angiotensin II blockade may improve not only hyperglycemia but also age-associated cardiac fibrosis. J Pharmacol Sci. 2009;109:275–284
  7. Swynghedauw B. Molecular mechanisms of myocardial remodeling. Physiol Rev. 1999;79:215–262
  8. Nocon M, Hiemann T, Müller-Riemenschneider F, Thalau F, Roll S, Willich SN. Association of physical activity with all-cause and cardiovascular mortality: a systematic review and meta-analysis. Eur J Cardiovasc Prev Rehabil. 2008;15:239–246
  9. Ehsani AA, Hagberg JM, Hickson RC. Rapid changes in left ventricular dimensions and mass in response to physical conditioning and deconditioning. Am J Cardiol. 1978;42:52–56
  10. Lakhan SE, Harle L. Cardiac fibrosis in the elderly, normotensive athlete: case report and review of the literature. Diagn Pathol. 2008;3:1–5
  11. Whyte G, Sheppard M, George K, Shave R, Wilson M, Prasad S, et al. Post-mortem evidence of idiopathic left ventricular hypertrophy and idiopathic interstitial myocardial fibrosis: is exercise the cause?. Br J Med. 2008;42:304–305
  12. Mika T, Yokota Y, Seo T, Yokoyama M. Echocardiographic findings in 104 professional cyclists with follow-up study. Am Heart J. 1994;127:898–905
  13. Lindsay MM, Dunn FG. Biochemical evidence of myocardial fibrosis in veteran endurance athletes. Br J Sports Med. 2007;41:447–452
  14. Nishimura T, Yamada Y, Kawai C. Echocardiographic evaluation of long-term effects of exercise on left ventricular hypertrophy and function in professional bicyclists. Circulation. 1980;61:832–840
  15. Diez J, Laviades C. Monitoring fibrillar collagen turnover in hypertensive heart disease. Cardiovasc Res. 1997;35:202–205
  16. Lopez B, Gonzalez A, Querejeta R, Diez J. The use of collagen-derived serum peptides for the clinical assessment of hypertensive heart disease. J Hypertens. 2005;23:1445–1451
  17. Querejeta R, Lopez B, Gonzalez A, Sanchez E, Larman M, Martinez Ubago JL, et al. Increased collagen type I synthesis in patients with heart failure of hypertensive origin. Relation to myocardial fibrosis. Circulation. 2004;110:1263–1268
  18. Lopez B, Gonzalez A, Beaumont J, Querejeta R, Larman M, Diez J. Identification of a potential cardiac antifibrotic mechanism of torasemide in patients with chronic heart failure. J Am Coll Cardiol. 2007;50:859–867
  19. Klappacher G, Franzen P, Haab D, Mehrabi M, Binder M, Plesch K. Measuring extracellular matrix turnover in the serum of patients with idiopathic or ischemic dilated cardiomyopathy and impact on diagnosis and prognosis. Am J Cardiol. 1995;75:913–918
  20. Weber KT. Monitoring tissue repair and fibrosis from a distance. Circulation. 1997;96:2488–2492
  21. Wang TJ, Larson MG, Benjamin EJ, Siwik DA, Safa R, Guo CY, et al. Clinical and echocardiographic correlates of plasma procollagen type III amino-terminal peptide levels in the community. Am Heart J. 2007;154:291–297
  22. Cornelissen VA, Arnout J, Holvoet P, Fagard RH. Influence of exercise at lower and higher intensity on blood pressure and cardiovascular risk factors at older age. J Hypertens. 2009;27:753–762
  23. Guidelines Committee . 2003 European Society of Hypertension-European Society of Cardiology guidelines for the management of arterial hypertension. J Hypertens. 2003;21:1011–1053
  24. Abellan R, Ventura R, Pichini S, Di Giovannandrea R, Bellver M, Olive R, et al. Effect of physical fitness and endurance on indirect biomarkers of recombinant growth hormone misuse: insulin-like growth factor I and procollagen type III peptide. Int J Sports Med. 2006;27:976–983
  25. Sartorio A, Lafortuna C, Copodaglio P, Vangeli V, Narici MV, Faglia G. Effects of a 16-week progressive high-intensity strength training on indexes of bone turnover in men over 65 years: a randomized controlled study. J Endocrinol Invest. 2001;24:882–886
  26. Fujimura R, Ashizawa N, Watanabe M, Mukai N, Amagai H, Fukubayashi T, et al. Effect of resistance exercise training on bone formation and resorption in young male subjects assessed by biomarkers of bone metabolism. J Bone Miner Res. 1997;12:656–662
  27. Escudero EM, Tufare AL, Rebolledo O, Pellegrini L, Lobrutto C. Serum carboxy-terminal propeptide of procollagen type I in exercise-induced left ventricular hypertrophy. Clin Cardiol. 2004;27:471–474
  28. Evans RK, Antczak AJ, Lester M, Yanovich R, Israeli E, Moran DS. Effects of a 4 month recruit training program on markers of bone metabolism. Med Sci Sports Exerc. 2008;40:S660–667
  29. Xu X, Wan W, Powers AS, Li J, Ji LL, Lao S, et al. Effects of exercise training on cardiac function and myocardial remodeling in post myocardial infarction rats. J Mol Cell Cardiol. 2008;44:114–122
  30. Xu X, Wan W, Ji L, Lao S, Powers AS, Zhao W, et al. Exercise training combined with angiotensin II receptor blockade limits post-infarct ventricular remodelling in rats. Cardiovasc Res. 2008;78:523–532

PII: S1440-2440(09)00175-3

doi: 10.1016/j.jsams.2009.08.001

Journal of Science and Medicine in Sport
Volume 13, Issue 4 , Pages 424-428 , July 2010

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