Abstract
Objectives
The A1470T polymorphism (rs1049434) in the monocarboxylate (lactate/pyruvate) transporter
1 gene (MCT1) has been suggested to influence athletic performance in the general population.
We compared genotype distributions and allele frequencies of the MCT1 gene A1470T polymorphism between endurance athletes, sprint/power athletes and matched
controls. We also examined the association between the MCT1 A1470T and the athletes’ competition level (‘elite’ and ‘national’ level).
Design
The study involved endurance athletes (n = 112), sprint/power athletes (n = 100), and unrelated sedentary controls (n = 621), all Caucasians.
Methods
Genomic DNA was extracted from buccal epithelium using a standard protocol. We conducted
Fisher's exact tests and multinomial logistic regression analyses to assess the association
between MCT1 genotype and athletic status/competition level.
Results
Sprint/power athletes were more likely than controls to possess the minor T allele
(TT genotype compared to the AA [p < 0.001]; TT or AT compared to the AA [p = 0.007]; TT compared to both AA and AT genotypes [p < 0.001]). Likewise, sprint/power athletes were more likely than endurance athletes
to have the TT genotype compared to the AA (p = 0.029) and the TT compared to both AA and AT genotypes (p = 0.027). Furthermore, elite sprint/power athletes were more likely than national-level
athletes to have the TT genotype compared to the AA (p = 0.044), and more likely to have the TT genotype compared to both AA and AT genotypes
(recessive model) (p = 0.045).
Conclusions
The MCT1 TT genotype is associated with elite sprint/power athletic status. Future studies
are encouraged to replicate these findings in other elite athlete cohorts.
Keywords
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Article info
Publication history
Published online: January 31, 2014
Accepted:
December 20,
2013
Received in revised form:
December 13,
2013
Received:
May 15,
2013
Identification
Copyright
© 2013 Sports Medicine Australia. Published by Elsevier Inc. All rights reserved.
