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Biological cell therapies for discogenic low back pain

      Introduction: Biological therapies use the body's natural mechanisms to treat disease. For lower back pain, therapies include a range of increasingly purified and targeted biological products from the blood derived platelet-rich plasma to the more specialised adipose tissue derived and expanded mesenchymal stem cells (MSCs). MSCs have been shown to reduce pain and induce repair in osteoarthritis and disc-related lower back pain. A study of 100 patients showed significant pain relief and improvements 24 months after therapy in patients with chronic lower back pain1 whilst a 10-patient study showed improvements in chronic low back pain as early as three months.2
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