The objective of this study was to assess sex differences in PPG responses to short stair stepping bouts, and to describe their intensity and metabolic cost.
34 participants (age: 25.9 ± 5.5 y; women = 14) underwent 4 oral glucose tolerance tests (OGTT) during rest or with stair-stepping bouts at self-selected, moderate pace for 1, 3, and 10 min. Blood was collected every 15 min during the OGTTs and assessed for glucose. Participants also underwent maximal aerobic capacity assessment. Expired gases were collected during capacity testing, and each stair-stepping bout.
Normalized to body weight there was no significant interaction for sex with stair-stepping trials (p = 0.445, ηp2= 0.03), or time (p = 0.069, ηp2= 0.09), or trial by time (p = 0.264, ηp2= 0.04). Women had higher mean glucose values than men (15(CI = 3, 27)%, p = 0.015). iAUC also showed no interaction of sex*trial (p = 0.059, ηp2= 0.09). Women had higher iAUC values (meanΔ = −29(−48, −11)%, p = 0.003). There was a main effect for trial with 10min showing the largest reduction from control for women (e.g. AUC −10(−6, −13)%, p < .001) and men (−8(2, 13)%, p = .010). Metabolic cost of the stair stepping bouts showed no interaction of sex*trial (p = 0.715, ηp2= 0.01) and no difference between sexes (meanΔ = −1.3(−5.9, 3.4)%, p = 0.571). Intensity was higher for women for the 3 min (60 ± 11 vs. 48 ± 9%VO2max, p = 0.003) and 10 min (67 ± 8 vs. 54 ± 12%VO2max, p = 0.002) bouts. Moreover, both sexes underestimated the true intensity of stepping.
Both sexes had similar responses to short bouts of exercise, which they perceived as less intense than indicated by objective assessment. Stair stepping reduces postprandial glucose response with similar effectiveness for both sexes.
ClinicalTrials.gov Identifier: NCT03400774.
Abbreviations:AUC (area under the curve), BMI (body mass index), CHO (carbohydrate), GE (gross efficiency), HbA1c (glycated hemoglobin), iAUC (incremental area under the curve), OGTT (oral glucose tolerance test), PPG (postprandial blood glucose), RPE (rating of perceived exertion), VO2max (maximal oxygen consumption)
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- Promoting the understanding of sex differences to enhance equity and excellence in biomedical science.Biol Sex Differ. 2010; 1: 1
- Sex bias in neuroscience and biomedical research.Neurosci Biobehav Rev. 2011; 35: 565-572
- Putting gender on the agenda.Nature. 2010; 465: 665
- Sex-specific differences in lipid and glucose metabolism.Front Endocrinol. 2015; 5: 241
- Sex differences in metabolic homeostasis, diabetes, and obesity.Biol Sex Differ. 2015; 6: 14
- Postprandial blood glucose as a risk factor for cardiovascular disease in type II diabetes: the epidemiological evidence.Diabetologia. 2001; 44: 2107-2114
- Impact of postprandial glycaemia on health and prevention of disease.Obes Rev. 2012; 13: 923-984
- Is nondiabetic hyperglycemia a risk factor for cardiovascular disease? A meta-analysis of prospective studies.Arch Intern Med. 2004; 164: 2147-2155
- Postprandial glucose regulation: new data and new implications.Clin Ther. 2005; 27: S42-S56
- Guideline for management of postmeal glucose.Nutr Metab Cardiovasc Dis. 2008; 18: S17-S33
- Sex differences in glucose and insulin trajectories prior to diabetes diagnosis: the Whitehall II study.Acta Diabetol. 2014; 51: 315-319
- Differences in height explain gender differences in the response to the oral glucose tolerance test—the AusDiab study.Diabet Med. 2008; 25: 296-302
- Differences in height explain gender differences in the response to the oral glucose tolerance test.Diabet Med. 2008; 25: 1374-1375
- Endurance exercise training attenuates leucine oxidation and BCOAD activation during exercise in humans.Am J Physiol Endocrinol Metab. 2000; 278: E580-E587
- Substrate utilization during endurance exercise in men and women after endurance training.Am J Physiol Endocrinol Metab. 2001; 280: E898-E907
- Breaks in sitting time: effects on continuously monitored glucose and blood pressure.Med Sci Sport Exerc. 2017; 49: 2119-2130
- Breaking up prolonged sitting with standing or walking attenuates the postprandial metabolic response in postmenopausal women: a randomized acute study.Diabetes Care. 2016; 39: 130-138
- Benefits for type 2 diabetes of interrupting prolonged sitting with brief bouts of light walking or simple resistance activities.Diabetes Care. 2016; 39: 964-972
- Recommendations for improved data processing from expired gas analysis indirect calorimetry.Sports Med. 2010; 40: 95-111
- Updating ACSM’s recommendations for exercise preparticipation health screening.Med Sci Sport Exerc. 2015; 47: 2473-2479
- Measuring perceived benefits and perceived barriers for physical activity.Am J Health Behav. 2005; 29: 107-116
- Measurement of substrate oxidation during exercise by means of gas exchange measurements.Int J Sports Med. 2005; 26: S28-S37
- Barriers to physical activity and socioeconomic position: implications for health promotion.J Epidemiol Community Health. 1999; 53: 191-192
- What is the best way to change self-efficacy to promote lifestyle and recreational physical activity? A systematic review with meta-analysis.Br J Health Psychol. 2010; 15: 265-288
- Associations between Borg’s rating of perceived exertion and physiological measures of exercise intensity.Eur J Appl Physiol. 2013; 113: 147-155
- Overall and differentiated ratings of perceived exertion at the respiratory compensation threshold: effects of gender and mode.Eur J Appl Physiol. 2003; 89: 445-450
- Relevance of the measure of perceived exertion for the rehabilitation of obese patients.Ann Phys Rehabil Med. 2012; 55: 623-640
- Type 2 diabetes exaggerates exercise effort and impairs exercise performance in older women.BMJ Open Diabetes Res Care. 2015; 3: 9
Published online: July 20, 2018
Accepted: July 13, 2018
Received in revised form: July 9, 2018
Received: February 8, 2018
© 2018 Published by Elsevier Ltd on behalf of Sports Medicine Australia.