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Lateral ankle instability-induced neuroplasticity in brain grey matter: A voxel-based morphometry MRI study

  • Author Footnotes
    1 Xiao'ao Xue and Yuyang Zhang as first authors contributed equally to this work.
    Xiao'ao Xue
    Footnotes
    1 Xiao'ao Xue and Yuyang Zhang as first authors contributed equally to this work.
    Affiliations
    Department of Sports Medicine, Huashan Hospital, Fudan University, China
    Search for articles by this author
  • Author Footnotes
    1 Xiao'ao Xue and Yuyang Zhang as first authors contributed equally to this work.
    Yuyang Zhang
    Footnotes
    1 Xiao'ao Xue and Yuyang Zhang as first authors contributed equally to this work.
    Affiliations
    Department of Radiology, Huashan Hospital, Fudan University, China
    Search for articles by this author
  • Shengkun Li
    Affiliations
    Department of Sports Medicine, Huashan Hospital, Fudan University, China
    Search for articles by this author
  • Hanlin Xu
    Affiliations
    Department of Sports Medicine, Huashan Hospital, Fudan University, China
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  • Author Footnotes
    2 Shuang Chen and Yinghui Hua as corresponding authors contributed equally to this work.
    Shuang Chen
    Correspondence
    Corresponding authors.
    Footnotes
    2 Shuang Chen and Yinghui Hua as corresponding authors contributed equally to this work.
    Affiliations
    Department of Radiology, Huashan Hospital, Fudan University, China
    Search for articles by this author
  • Author Footnotes
    2 Shuang Chen and Yinghui Hua as corresponding authors contributed equally to this work.
    Yinghui Hua
    Correspondence
    Corresponding authors.
    Footnotes
    2 Shuang Chen and Yinghui Hua as corresponding authors contributed equally to this work.
    Affiliations
    Department of Sports Medicine, Huashan Hospital, Fudan University, China
    Search for articles by this author
  • Author Footnotes
    1 Xiao'ao Xue and Yuyang Zhang as first authors contributed equally to this work.
    2 Shuang Chen and Yinghui Hua as corresponding authors contributed equally to this work.

      Abstract

      Objectives

      The deficits in sensory pathways caused by peripheral edema, pain, and inflammation of the damaged ligaments may induce maladaptive changes within the central nervous system. The purpose of this study was to determine whether patients with lateral ankle instability (LAI) exhibit morphological differences of brain grey matter when compared with healthy controls, and then assess the relationships between the observed differences and the characteristics of patients.

      Design

      Cross-sectional.

      Methods

      Thirty patients with LAI and 32 healthy controls without LAI underwent MRI scans using anatomical T1 sequences. A voxel-wise general linear model was used to compare the grey matter volume throughout the whole brain between patients and controls. Linear regression analyses were performed for the grey matter volume within the significant clusters to assess their relationship with age, sex, the existence of acute injury, pain level, sports activity level, and the duration of LAI within the patient group.

      Results

      The grey matter volume of a cluster within the cerebellar vermis (Vermis_4_5 in automated anatomical labeling template) was significantly reduced in patients with LAI (Gaussian Random Field corrections with two-tailed p-cluster < 0.05 and p-voxel < 0.001). Multivariate linear regression analysis revealed that the duration of LAI tended to be passively associated with the grey matter volume of this LAI-related vermal cluster (p = 0.092).

      Conclusions

      Participants with LAI exhibited a reduced grey matter volume of a cluster within the cerebellar vermis compared with participants without LAI, and the degree of volume reduction tended to be positively associated with the duration of LAI.

      Keywords

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