S108| Volume 24, SUPPLEMENT 1, S15, November 2021

Light to vigorous exercise up-regulates TERT gene expression and telomerase in numerous tissues

      Background: Telomeres are a repeat sequence of DNA (in mammals, TTAGGGn) found at the distal ends of chromosomes that protect genomic integrity. Telomeres gradually shorten with each round of cell division which ultimately reduces tissue vitality. Short leukocyte telomeres are often observed in patients with age-related and degenerative diseases, and accelerated telomere shortening is associated with adverse lifestyle factors, such as psychological distress. Telomerase is an enzyme capable of lengthening telomeres. To that end, we conducted a systematic review and meta-analysis to determine the effects of acute exercise and chronic exercise training on telomerase reverse transcriptase (TERT) gene and telomerase enzyme activity in healthy humans and rodents.
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