Background: Telomeres are a repeat sequence of DNA (in mammals, TTAGGGn) found at the distal
ends of chromosomes that protect genomic integrity. Telomeres gradually shorten with
each round of cell division which ultimately reduces tissue vitality. Short leukocyte
telomeres are often observed in patients with age-related and degenerative diseases,
and accelerated telomere shortening is associated with adverse lifestyle factors,
such as psychological distress. Telomerase is an enzyme capable of lengthening telomeres.
To that end, we conducted a systematic review and meta-analysis to determine the effects
of acute exercise and chronic exercise training on telomerase reverse transcriptase
(TERT) gene and telomerase enzyme activity in healthy humans and rodents.
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