Abstract
Objective
The study was designed to investigate the role of exercise in ameliorating endothelial
function and hemodynamics in postmenopausal females, and compare the different effects
of high-intensity interval training and moderate-intensity continuous training by
equalizing training load.
Design
Randomized controlled trial.
Methods
First intervention, 30 volunteers were randomized into low-intensity continuous training
group or sedentary group. The low-intensity continuous training group was assigned
to a 12-week training program at an intensity of 40% maximum heart reserve. The second
intervention was an 8-week training program, in which 18 individuals were randomly
placed either in the moderate-intensity continuous training or high-intensity interval
training group. Flow-mediated dilatation, blood samples, carotid ultrasound, and wall
shear stress were collected before, during, and after the interventions.
Results
Flow-mediated dilatation was significantly increased in low-intensity continuous training
group (p = 0.02), moderate-intensity continuous training (p = 0.023) and high-intensity
interval training (p < 0.01) groups, with a time × group interaction for %FMD (F2, 32 = 4.421, p = 0.02), and a main effect of time (F2, 32 = 27.658, p < 0.001). Nitric oxide in low-intensity continuous training increased
remarkably (p = 0.024) and was higher than that in control (p = 0.011). High-intensity
interval training (p < 0.001) and moderate-intensity continuous training (p < 0.001)
increased nitric oxide. Endothelin was decreased only in high-intensity interval training
group (p = 0.049). All the training programs had a remarkable impact on wall shear
stress.
Conclusions
Low-intensity continuous training can improve endothelial function in postmenopausal
females. High-intensity interval training could be an effective training regimen for
improving endothelial function than moderate-intensity continuous training in postmenopausal
females.
Keywords
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Article info
Publication history
Published online: February 01, 2022
Accepted:
January 28,
2022
Received in revised form:
January 26,
2022
Received:
September 23,
2021
Identification
Copyright
© 2022 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.
