Handgrip strength is considered a vital and reliable measure of comprehensive physical assessments, whereas the association of handgrip strength with overall mortality risk among Chinese adults was less studied. We prospectively investigated the association between handgrip strength and all-cause mortality among Chinese middle-aged and older people based on data from the China Health and Retirement Longitudinal Study (CHARLS).
3CHARLS: China Health and Retirement Longitudinal Study.
Longitudinal cohort study.
Grip strength was assessed for both hands by a dynamometer. Odds ratios (ORs)
4ORs: odds ratios.and 95 % confidence intervals (CIs)
5CIs: confidence intervals.were estimated applying logistic regression models with adjustments for age, body mass index, ethnicity, education level, annual household income, marital status, drinking, smoking, physical activity, and medical insurance among men and women. Deaths were ascertained by each follow-up survey in which the household member who lived with the participants were inquired.
Over an average follow-up period of approximately 8 years among the screened 11,618 participants ≥45 years old, 1290 deaths were documented. The age range was 45–93 for men and 45–96 for women. Greater handgrip strength was associated with a lower overall mortality risk, with adjusted ORs (comparing with extreme tertiles) of 0.47 (95 % CI: 0.35–0.64; P-trend<0.001) in men and 0.51 (95 % CI: 0.24–1.08; P-trend = 0.059) in women. Such inverse association seemed stronger among younger men (OR = 0.29, 95 % CI: 0.18–0.45), compared with the older men (OR = 0.49, 95 % CI: 0.33–0.73; P-interaction = 0.023).
Handgrip strength was inversely associated with all-cause mortality risk, especially among the younger men. Further investigations are warranted to elucidate the underlying mechanism.
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- Social class, race/ethnicity and all-cause mortality in the US: longitudinal results from the 1986-1994 National Health Interview Survey.Eur J Epidemiol. 2004; 19: 777-784
- Analysis on all-cause mortality rate and life expectancy in China, 2005-2018.Zhonghua Liu Xing Bing Xue Za Zhi. 2021; 42: 1420-1428
- Grip strength measurement : significance and boundaries.Orthopade. 2018; 47: 191-197
- Handgrip strength and mortality in the oldest old population: the Leiden 85-plus study.Cmaj. 2010; 182: 429-435
- Effects of exercise training on handgrip strength in older adults: a meta-analytical review.Gerontology. 2019; 65: 686-698
- Associations of grip strength with cardiovascular, respiratory, and cancer outcomes and all cause mortality: prospective cohort study of half a million UK Biobank participants.Bmj. 2018; 361k1651
- Handgrip strength and all-cause mortality in middle-aged and older Koreans.Int J Environ Res Public Health. 2019; 16
- Sex, race and age differences in muscle strength and limitations in community dwelling older adults: data from the Health and Retirement Survey (HRS).Arch Gerontol Geriatr. 2016; 65: 98-103
- A research agenda for ageing in China in the 21st century (2nd edition): focusing on basic and translational research, long-term care, policy and social networks.Ageing Res Rev. 2020; 64101174
- Association of handgrip strength with the prevalence of hypertension in a Chinese Han population.Chronic Dis Transl Med. 2019; 5: 113-121
- Association between relative handgrip strength and hypertension in Chinese adults: an analysis of four successive national surveys with 712,442 individuals (2000-2014).PLoS One. 2021; 16e0258763
- Cohort profile: the China Health and Retirement Longitudinal Study (CHARLS).Int J Epidemiol. 2014; 43: 61-68
- Association of walking pace and handgrip strength with all-cause, cardiovascular, and cancer mortality: a UK Biobank observational study.Eur Heart J. 2017; 38: 3232-3240
- International physical activity questionnaire: 12-country reliability and validity.Med Sci Sports Exerc. 2003; 35: 1381-1395
- Level of physical activity among middle-aged and older Chinese people: evidence from the China health and retirement longitudinal study.BMC Public Health. 2020; 20: 1682
- New normative values for handgrip strength: results from the UK Biobank.J Am Med Dir Assoc. 2013; 14 (775.e5–11)
- Prognostic value of grip strength: findings from the Prospective Urban Rural Epidemiology (PURE) study.Lancet. 2015; 386: 266-273
- Thigh circumference and handgrip strength are significantly associated with all-cause mortality: findings from a study on Japanese community-dwelling persons.Eur Geriatr Med. 2021; 12: 1191-1200
- Objectively measured physical capability levels and mortality: systematic review and meta-analysis.Bmj. 2010; 341c4467
- Musculoskeletal fitness and risk of mortality.Med Sci Sports Exerc. 2002; 34: 740-744
- Gender differences in the association between grip strength and mortality in older adults: results from the KORA-age study.BMC Geriatr. 2016; 16: 201
- Association between muscular strength and mortality in men: prospective cohort study.Bmj. 2008; 337a439
- Physical activity in older age: perspectives for healthy ageing and frailty.Biogerontology. 2016; 17: 567-580
- Gender and the regulation of longevity: implications for autoimmunity.Autoimmun Rev. 2012; 11: A393-A403
- Sarcopenia in the elderly.Fam Pract. 2012; 29 (i44-i8)
- Disability, physical activity, and muscle strength in older women: the Women’s Health and Aging Study.Arch Phys Med Rehabil. 1999; 80: 130-135
- Factors associated with mortality after hip fracture.Osteoporos Int. 2000; 11: 228-232
- Hyperinsulinaemia: the key feature of a cardiovascular and metabolic syndrome.Diabetologia. 1991; 34: 416-422
- Association between sarcopenia and cardiovascular disease among middle-aged and older adults: findings from the China health and retirement longitudinal study.EClinicalMedicine. 2022; 44101264
- Validity and usefulness of hand-held dynamometry for measuring muscle strength in community-dwelling older persons.Arch Gerontol Geriatr. 2012; 54: 21-27
Published online: August 14, 2022
Accepted: August 12, 2022
Received in revised form: August 10, 2022
Received: April 21, 2022
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