Abstract
Objectives
Endurance exercise is known to cause a rise in serum creatinine. It is not known to
what extent this rise reflects renal stress and a potential acute kidney injury (AKI).
Increases in Insulin Like Growth Factor Binding Protein 7 (IGFBP7) and Tissue Inhibitor
of Metalloprotinases-2 (TIMP-2), urinary biomarkers of cell cycle arrest and renal
stress, are associated with the development of AKI in clinical populations.
Design
Repeated measures study.
Methods
Runners were recruited at the 2019 Brighton Marathon (UK) and provided urine and blood
samples at baseline, immediately post-race and 24 h post-race. Serum creatinine, urinary
creatinine and urinary IGFBP7 and TIMP-2 were analysed from the samples.
Results
Seventy nine participants (23 females, 56 males), aged 43 ± 10 yrs. (mean ± SD), finish
time 243 ± 40mins were included for analysis. Serum creatinine increased over the
race by 40 ± 26% (p < 0.001), TIMP-2 increased by 555 ± 697% (p < 0.001) and IGFBP7 increased by 1094 ± 1491% (p < 0.001) over the race. A subset of twenty-two participants supplied samples 24 h
post-race, reporting values similar to baseline for all variables.
Conclusions
This study is the first to report large rises in IGFBP7 and TIMP-2 following marathon
running. This suggests that rises in creatinine are not fully explained by changes
in production and clearance and marathon running induces a state of kidney stress
and potential injury.
Keywords
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Article info
Publication history
Published online: October 24, 2022
Accepted:
October 22,
2022
Received in revised form:
September 22,
2022
Received:
June 25,
2022
Footnotes
☆Author contributions statement - all authors were involved with:
☆Substantial contributions to the conception or design of the work; or the acquisition, analysis, or interpretation of data for the work; AND
☆Drafting the work or revising it critically for important intellectual content; AND
☆Final approval of the version to be published; AND
☆Agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
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